Test Applications in an Organotypic Environment A Novel Test Concept for In Vitro Pharmacotoxicology	TAO Home
TAO Home The Concept Test Design Human Tissue Highlights Contact Overview (PDF)			Sabine Kloth, PhD Lecturer for Anatomy and Cell Biologist, University of Regensburg, Germany Education Dr. med. habil., Dept. of Anatomy, University of Regensburg, Germany, 1996 Ph.D. in Cell Biology, Research Center Borstel, University of Kiel, Germany, 1989 M.Sc. in Biology, University of Kiel, Germany, 1985
			Research Objectives Physiological and developmental function of cellular interactions during organogenesis Regulatory roles of growth and differentiation factors for blood vessel development and the maturation of the vessel wall Design of tissue culture concepts for tissue engineering, pharmacological investigation and toxicity testing
			Relevant Publications S. Kloth, K. Kobuch, J. Domokos, C. Wanke, J. Monzer (2000): Polar application of test substances in an organotypic environment and under continuous medium flow: A new tissue-based test concept for applications in pharmacotoxicology. Toxicology in Vitro 14, 265-274. S. Kloth, E. Eckert, S. J. Klein, J. Monzer, C. Wanke, W. W. Minuth (1998): Long-term preservation of the gastric epithelium under organotypic perfusion culture. In Vitro Cell. Dev. Biol. A34, 515-517. S. Kloth, J. Gerdes, C. Wanke, W. W. Minuth (1998): Basic fibroblast growth factor (bFGF) is a morphogenic modulator in kidney vessel development. Kidney Int. 53, 970-978. S. Kloth, C. Ebenbeck, M. Kubitza, A. Schmidbauer, R. Röckl and W. W. Minuth (1995): Stimulatory effects of different growth factors on the development of the renal microvasculature under organotypic culture conditions. FASEB J. 9, 963-967.
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			Sabine Kloth, PhD Goldshausener Str. 1a D-85417 Marzling GERMANY Phone: +49-8161-65968
			German and US Patents © 2003 Sabine Kloth