Test Applications in an Organotypic Environment A Novel Test Concept for In Vitro Pharmacotoxicology
The Concept Test Design Human Tissue Highlights Contact Overview (PDF)			The Concept Pharmacological studies and toxicity tests are performed with in vitro cultures of differentiated tissue. The differentiated state of cultured tissue has been demonstrated for periods of up to several weeks. Our culture technology is applicable for tissues of most mammalian species -- including human.
			Test Design Test compounds are administered to tissue cultures in a polar fashion using a gradient culture chamber. This experimental design mimics common in vivo pathways of drug and chemical exposition, where compounds access the organism across epithelial surfaces. Continuous medium supply safeguards excellent tissue preservation over prolonged culture intervals in the range of several weeks.
			Highlights Utilises tissues of the target organism, including human Capacity to use small amounts of test compounds Potential for on-line measurements and for test automation
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			Contact and Inquiries Inquiries regarding the TAO in vitro tissue culture test concept or licensing opportunities are kindly requested. Find out more about the author's scientific expertise. Sabine Kloth, PhD Goldshausener Str. 1a D-85417 Marzling GERMANY Phone: +49-8161-65968
			German and US Patents © 2003 Sabine Kloth